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Lapatinib
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Summary
General Info
Genetic Markers
Most Correlated Genes
CPVL
ID4
RBP4
SERPINA3
CYP4B1
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Pathway Enrichment
Most Correlated Biogroups
cytosol
organic cyclic compound binding
heterocyclic compound binding
PUJANA_BRCA1_PCC_NETWORK
DODD_NASOPHARYNGEAL_CARCINOMA_DN
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Curated Studies
Most Correlated Studies
Acquired resistance to lapatinib in breast cancer cell lines
Breast adenocarcinoma SKR6 cells activation of NF-KB pathway and lapatinib resistance
Breast cancer SK-BR-3 cells treated with FAK and/or EGFR/HER-2 small molecule inhibitors
Breast cancer SK-BR-3 cells with ERRalpha (ESRRA) siRNA knockdown treated with EGF or heregulin
Lapatinib resistance-associated gene expression in a breast cancer cell line
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Literature
Most Relevant Literature
Lapatinib: A comprehensive profile.
The effect of shikonin on the metabolism of lapatinib in vitro, and in vivo.
Concurrent Lapatinib With Brain Radiation Therapy in Patients With HER2+ Breast Cancer With Brain Me…
Enhancement in the therapeutic potential of lapatinib ditosylate against breast cancer by the use of…
Macrophages M2 polarization is involved in lapatinib-mediated chemopreventive effects in the lung ca…
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Clinical Trials
Most Relevant Clinical Trials
Lapatinib in Combination With Vinorelbine
Lapatinib With Sirolimus or Metformin
Lapatinib in Combination With Vinorelbine
Lapatinib and Trastuzumab With or Without Endocrine Therapy
Concentration and Activity of Lapatinib in Vestibular Schwannomas
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