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MLN4924
(compound)
Summary
General Info
Genetic Markers
Most Correlated Genes
OLFML2B
COL3A1
POSTN
DUSP8
TPSB2
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Pathway Enrichment
Most Correlated Biogroups
heterocyclic compound binding
nucleoplasm
organic cyclic compound binding
regulation of nitrogen compound metabolic process
heterocycle metabolic process
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Curated Studies
Most Correlated Studies
Melanoma A375 cells with p53, CDT1 or BRCA1 knockdown and daunorubicin, nutlin or MLN4924 treatment
Chronic lymphocytic leukemia cells treated with MLN4924
Acute erythroleukemia HEL cells treated with ruxolitinib, pevonedistat, or both
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (3 of 4)
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (2 of 4)
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Literature
Most Relevant Literature
Neddylation-Independent Activities of MLN4924.
Deneddylation of ribosomal proteins promotes synergy between MLN4924 and chemotherapy to elicit comp…
Integrated analysis reveals the regulatory mechanism of the neddylation inhibitor MLN4924 on the met…
The NEDD8 activating enzyme inhibitor MLN4924 mitigates doxorubicin-induced cardiotoxicity in mice.
Neddylation inhibitor MLN4924 sensitizes head and neck squamous carcinoma cells to (S)-10-hydroxycam…
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Clinical Trials
Most Relevant Clinical Trials
MLN4924 Compared With MLN4924 Plus Chemotherapy for Large B-cell Lymphoma
Study of MLN4924 in Adult Patients With Nonhematologic Malignancies
Dose Escalation Study of MLN4924 in Adults With Melanoma
Effects of Fluconazole and Itraconazole CYP3A-Mediated Inhibition on the Pharmacokinetics, Safety, a…
Study of MLN4924, a Novel Inhibitor of Nedd8 Activating Enzyme, in Adult Patients With Lymphoma or M…
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