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Nutlin-3
(compound)
Summary
General Info
Genetic Markers
Most Correlated Genes
INPP5D
GPR87
SERPINB5
CDKN1A
FAS
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Pathway Enrichment
Most Correlated Biogroups
FISCHER_DREAM_TARGETS
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP
DUTERTRE_ESTRADIOL_RESPONSE_24HR_UP
FISCHER_DIRECT_P53_TARGETS_META_ANALYSIS
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP
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Curated Studies
Most Correlated Studies
Melanoma A375 cells with p53, CDT1 or BRCA1 knockdown and daunorubicin, nutlin or MLN4924 treatment
MCF7 breast cancer cells expression profiles upon nutlin3a treatment
Effect of stresses on p53 binding and transactivation landscape in human cancer cells
Sarcoma tumor samples response to Nutlin-3a
Breast cancer MCF7 cell polysomal or subpolysomal RNA after doxorubicin or nutlin-3A treatment
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Literature
Most Relevant Literature
Nutlin-3 acts as a DNA methyltransferase inhibitor to sensitize esophageal cancer to chemoradiation.
MDM2 Antagonist Nutlin-3 Stimulates Global DNA Hydroxymethylation by Enhancing p53-TET1 Signaling Ax…
Proteasome Inhibition Sensitizes Liposarcoma to MDM2 Inhibition with Nutlin-3 by Activating the ATF4…
Murine Double Minute 2 Antagonist Nutlin-3 Enhanced Chemosensitivity in Esophageal Squamous Cell Car…
Sustained correction of hippocampal neurogenic and cognitive deficits after a brief treatment by Nut…
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Clinical Trials
Most Relevant Clinical Trials
Open Label Study of Single Agent Oral RG7388 in Patients With Polycythemia Vera and Essential Thromb…
Study of the Effect of SNPs in p53 and p53 Response Elements on the Inflammatory Response to DNA Dam…
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