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QuickView for PD173074 (compound)


Genetic Markers

Most Correlated Genes

  1. RBP4
  2. SERPINA3
  3. GPM6A
  4. XIST
  5. CEACAM6
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Pathway Enrichment

Most Correlated Biogroups

  1. organic cyclic compound binding
  2. heterocyclic compound binding
  3. regulation of nitrogen compound metabolic process
  4. organic cyclic compound metabolic process
  5. nucleoplasm
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Curated Studies

Most Correlated Studies

  1. FGFR2 signaling in MCF7 breast cancer cells
  2. Bladder cancer MGH-U3 cells with FGFR3 Y375C mutation and TAK1 siRNA treated with PD 173074
  3. ESC-like cell populations derived from pluripotent epiblast stem cells
  4. L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (3 of 4)
  5. L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (2 of 4)
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Literature

Most Relevant Literature

  1. The FGFR inhibitor PD173074 binds to the C-terminus of oncofetal HMGA2 and modulates its DNA-binding…
  2. The FGF receptor inhibitor PD173074 modulates Lefty expression in human induced pluripotent stem cel…
  3. NMR backbone assignments of the tyrosine kinase domain of human fibroblast growth factor receptor 3 …
  4. FGFR1 selective inhibitor PD173074 can reduce proliferation and induce apoptosis of nasopharyngeal c…
  5. Targeted PARP Inhibition Combined with FGFR1 Blockade is Synthetically Lethal to Malignant Cells in …
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Clinical Trials

Most Relevant Clinical Trials

  1. BIBF 1120 as Second Line Treatment for Small Cell Lung Cancer
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