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QuickView for PKC412 (compound)


Genetic Markers

Most Correlated Genes

  1. CXCL8
  2. ANKRD1
  3. TNF
  4. CTGF
  5. CXCL10
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Pathway Enrichment

Most Correlated Biogroups

  1. DACOSTA_UV_RESPONSE_VIA_ERCC3_DN
  2. BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP
  3. KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_UP
  4. regulation of nitrogen compound metabolic process
  5. DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP
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Curated Studies

Most Correlated Studies

  1. Acute myeloid leukemia MV-4-11 cells with drug sensitivity or resistance to PKC412
  2. Triple negative breast cancer cell lines treated with PKC412
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Literature

Most Relevant Literature

  1. Inhibitory Effect of PKC412 Against Human Acute Leukemia Cell Line HL-60 Cells].
  2. Kinase Inhibition by PKC412 Prevents Epithelial Sheet Damage in Autosomal Dominant Epidermolysis Bul…
  3. ETV6-NTRK3 as a therapeutic target of small molecule inhibitor PKC412.
  4. Sensitivity of AML Cells with FLT3- to PKC412 In Vitro].
  5. The secondary FLT3-ITD F691L mutation induces resistance to AC220 in FLT3-ITD+ AML but retains in vi…
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Clinical Trials

Most Relevant Clinical Trials

  1. PKC412 and 5-Azacytidine
  2. RAD001 in Combination With PKC412 in Patients With Relapsed, Refractory or Poor Prognosis AML or MDS
  3. PKC412 in Participants With Acute Myeloid Leukemia or With Myelodysplastic Syndrome (CPKC412A2104 Co…
  4. PKC412, Daunorubicin, and Cytarabine in Treating Patients With Newly Diagnosed Acute Myeloid Leukemi…
  5. Managed Access Programs for PKC412, Midostaurin
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