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Protein arginine methyltransferases
Summary
General Info
Curated Studies
Most Correlated Studies
Glioblastoma U-87MG cells treated with EPZ015666, a protein arginine methyltransferase inhibitor
Microvascular endothelial HMEC-1 cells treated with methyltransferase inhibitors AMI-1 and AMI-5
Breast cancer MCF7 ESA+ CD24low CD44+ cells with shRNA knockdown of methyltransferase PRMT5
K-562 cells expressing AE9a, a spliced form of AML-ETO, and depleted of interacting protein PRMT1
Pancreatic cell lines treated with chromatin-targeting small molecules
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Literature
Most Relevant Literature
Taming PRMT5-adaptor protein interactions.
Arginine methylation of PPP1CA by CARM1 regulates glucose metabolism and affects osteogenic differen…
Role of Coactivator Associated Arginine Methyltransferase 1 (CARM1) in the Regulation of the Biologi…
Systematic pan-cancer landscape identifies CARM1 as a potential prognostic and immunological biomark…
CARM1/PRMT4: Making Its Mark beyond Its Function as a Transcriptional Coactivator.
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Clinical Trials
Most Relevant Clinical Trials
AMG 193, Methylthioadenosine (MTA) Cooperative Protein Arginine Methyltransferase 5 (PRMT5) Inhibito…
The Pancreatic and Periampullary Resection Arginine Immunomodulation (PRIMe) Trial
Investigation of Methylation of EGFR in the Response of the Cetuximab in Metastatic Colorectal Cance…
A Study to Investigate Safety and Tolerability of SH3765 Tablet in Patients With Advanced Malignant …
A Study of PRT811 in Participants With Advanced Solid Tumors, CNS Lymphoma and Gliomas
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