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RyR1
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NextBio Summary
General Info
Body Atlas
Most Correlated Tissues
Skeletal muscle
Skeletal muscle psoas
Jejunum
Tongue main corpus
Extraocular muscle
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Disease Atlas
Most Correlated Diseases
Complication of anesthesia
Myopathy
Effects of heat
Pneumocystosis
Huntington's disease
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Pharmaco Atlas
Most Correlated Compounds
Dantrolene
tolfenamic acid
4-hydroxyestradiol-17 beta
Shh protein, mouse
N-acetylmuramic acid
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Knockdown Atlas
Most Correlated Gene Perturbations
SV40_Large_T_and_small_t_Ag_common-S
HIVEP2
HTT
SERPINA3
HTT
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Curated Studies
Most Correlated Studies
OMIM - Fever
Corneal endothelial HCEnC-21T cells with ZEB1 heterozygous mutation rescued by ZEB1 expression
Brain striata from Huntington's disease model mice treated with HSP90 inhibitor (HSP990)
Callus tissue during fracture healing from Krm2 transgenic or Lrp5-/- osteoporotic mice
HEK-293, HeLa, and SH-SY5Y cells with schizophrenia-associated miRNA inhibition and overexpression
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Literature
Most Relevant Literature
Interactive Roles of CaMKII/Ryanodine Receptor Signaling and Inflammation in Lung Diseases.
The Ca2+ permeation mechanism of the ryanodine receptor revealed by a multi-site ion model.
Investigating dual Ca2+ modulation of the ryanodine receptor 1 by molecular dynamics simulation.
Structural basis for diamide modulation of ryanodine receptor.
3D dSTORM imaging reveals novel detail of ryanodine receptor localization in rat cardiac myocytes.
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Clinical Trials
Most Relevant Clinical Trials
S 48168 (ARM 210) for the Treatment of RYR1-related Myopathies (RYR1-RM)
Multisystem Features of Malignant Hyperthermia or Rhabdomyolysis Related to RYR1 Variants
Spanish Registry of RYR1 and CACNA1S Polymorphisms
Antioxidant Therapy in RYR1-Related Congenital Myopathy
Contractile Cross Sectional Areas and Muscle Strength in Patients With Congenital Myopathies
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