QuickView for SMCR8 (gene)

1. C9orf72-associated SMCR8 protein binds in the ubiquitin pathway and with proteins linked with neurol…
2. Smcr8 deficiency disrupts axonal transport-dependent lysosomal function and promotes axonal swelling…
3. C9orf72 and smcr8 mutant mice reveal MTORC1 activation due to impaired lysosomal degradation and exo…
4. Reversing lysosome-ribosome circuit dysregulation mitigates C9FTD/ALS neurodegeneration and behavior…
5. Excessive endosomal TLR signaling causes inflammatory disease in mice with defective SMCR8-WDR41-C9O…

There were no clinical trials for SMCR8