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UCN-01
Summary
General Info
Curated Studies
Most Correlated Studies
HCT116 colon carcinoma cells - gene expression profiles in response to Chk1 inhibition or cisplatin
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Literature
Most Relevant Literature
The structural basis for high affinity binding of α1-acid glycoprotein to the potent antitumor compo…
Specific, reversible G1 arrest by UCN-01 in vivo provides cytostatic protection of normal cells agai…
Caspase-9 mediates Puma activation in UCN-01-induced apoptosis.
MK-8776, a novel Chk1 inhibitor, exhibits an improved radiosensitizing effect compared to UCN-01 by …
UCN-01 enhances cytotoxicity of irinotecan in colorectal cancer stem-like cells by impairing DNA dam…
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Clinical Trials
Most Relevant Clinical Trials
A Phase II Study of UCN-01 in Metastatic Melanoma
Cytarabine and UCN-01 in Treating Patients With Refractory or Relapsed Acute Myelogenous Leukemia or…
A Phase I Trial of Continuous Infusion UCN-01 in Patients With Refractory Neoplasms
Fluorouracil Plus UCN-01 in Treating Patients With Advanced or Refractory Solid Tumors
UCN-01 and Carboplatin in Treating Patients With Advanced Solid Tumors
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