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QuickView for ZMPSTE24 (gene)


Body Atlas

Most Correlated Tissues

  1. Basophil of peripheral blood
  2. Colon mucosa
  3. Smooth muscle
  4. Microglial cell
  5. Extraocular muscle
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Disease Atlas

Most Correlated Diseases

  1. Fibrotic disorder of skin
  2. Emery-Dreifuss muscular dystrophy
  3. Hutchinson-Gilford syndrome
  4. Subcutaneous fat disorder
  5. Dysostosis
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Pharmaco Atlas

Most Correlated Compounds

  1. verteporfin
  2. Practolol
  3. Fludrocortisone
  4. Ecdysone
  5. 5-chloro-1-(4-chlorobenzyl)-3-(phenylthio)indole-2-carboxylic acid
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Knockdown Atlas

Most Correlated Gene Perturbations

  1. Ar
  2. MIR122
  3. TYROBP
  4. MN1
  5. ERCC6
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Curated Studies

Most Correlated Studies

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Literature

Most Relevant Literature

  1. Abolishing the prelamin A ZMPSTE24 cleavage site leads to progeroid phenotypes with near-normal long…
  2. Targeting RAS-converting enzyme 1 overcomes senescence and improves progeria-like phenotypes of ZMPS…
  3. Deficiency in ZMPSTE24 and resulting farnesyl-prelamin A accumulation only modestly affect mouse adi…
  4. Overlapping function of Hrd1 and Ste24 in translocon quality control provides robust channel surveil…
  5. ZMPSTE24 defends against influenza and other pathogenic viruses.
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Clinical Trials

Most Relevant Clinical Trials

  1. Accelerated Aging, HIV Infection, Antiretroviral Therapies
  2. The LD Lync Study - Natural History Study of Genetic Lipodystrophy Syndromes
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