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allosteric site
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Curated Studies
Most Correlated Studies
A549 cells cultured with or without serine treated with Compound 16
Prostate cancer LNCaP cells overexpressing BAG1 mutant or wildtype alleles and treated with DHT
Breast cancer cell lines and xenografts treated with PI3KA or AKT inhibitors
Hepatocellular carcinomas treated with PI3K/mTOR inhibitors
Breast adenocarcinoma MCF7 and colon carcinoma HCT116 cells treated w/ small molecule AKT inhibitor
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Literature
Most Relevant Literature
Exploiting protein flexibility to predict the location of allosteric sites.
Communication between the active site and the allosteric site in class A beta-lactamases.
Equilibrium fluctuations of a single folded protein reveal a multitude of potential cryptic alloster…
A geometry-based generic predictor for catalytic and allosteric sites.
A bifunctional allosteric site in the dimer interface of procaspase-3.
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Clinical Trials
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Phase I Dose Escalation Study With an Allosteric AKT 1/2 Inhibitor in Patients
Studies of Sulfur Metabolism in Humans
A Study of HS-10382 in Patients With Chronic Myeloid Leukemia.
D-Serine Treatment For Tardive Dyskinesia
Specific Effects of Escitalopram on Neuroendocrine Response
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