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genes BRCA2
NextBio Summary
General Info
Curated Studies
Most Correlated Studies
MCF7 breast cancer cells expressing siRNAs targeting transcription factors and signaling molecules
Breast cancer tumors of women ≤ 35 years of age with BRCA1, BRCA2, and TP53 germline mutations
Ovarian and fallopian tube tissues of breast cancer patients with mutated BRCA1 or BRCA2
Mammary gland epithelial HME1 cells cultured in EGF-free medium after recovery from BRCA2-depletion
Non-malignant fallopian tube epithelium and high grade serous carcinoma
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Literature
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The functional impact of variants of uncertain significance in BRCA2.
Up-regulation of the interferon-related genes in BRCA2 knockout epithelial cells.
Identification of Variants (rs11571707, rs144848, and rs11571769) in the BRCA2 Gene Associated with …
Risk of colorectal cancer associated with BRCA1 and/or BRCA2 mutation carriers: systematic review an…
Calibration of Pathogenicity Due to Variant-Induced Leaky Splicing Defects by Using BRCA2 Exon 3 as …
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Clinical Trials
Most Relevant Clinical Trials
Study of Mitomycin-C in Patients With Advanced or Recurrent Pancreatic Cancer With Mutated BRCA2 Gen…
Prostate Cancer Screening in Men With Germline BRCA2 Mutations
Telephone-Based Genetic Counseling or Standard Genetic Counseling in Women at Risk of Carrying the B…
Olaparib, Durvalumab, and Tremelimumab in Treating Patients With Recurrent or Refractory Ovarian, Fa…
Study With Trabectedin in BRCA1 and BRCA2 Mutation Carrier and BRCAness Phenotype Ovarian Cancer
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