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lipoxygenase inhibitors
(compound)
Summary
General Info
Genetic Markers
Most Correlated Genes
STAC3
ALOX15
CYP1A1
AZGP1
NREP
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Pathway Enrichment
Most Correlated Biogroups
response to organic substance
response to stress
organic cyclic compound binding
heterocyclic compound binding
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP
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Curated Studies
Most Correlated Studies
Acute monocytic leukemia THP-1 cells treated with plant derived P4N compound
MK886 treatment of and gene knockdown of HNRPA2B1 and ALOX5AP in lung cancer cell lines
Livers of rat exposed to variety of hepatotoxic compounds
Drug Matrix In Vivo Toxicogenomic Study - Rat Liver [Affymetrix]
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (1 of 4)
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Literature
Most Relevant Literature
QSAR study on 5-lipoxygenase inhibitors based on support vector machine.
6'-Hydroxyoxosorbicillinol, a new lipoxygenase inhibitor and PGD2/LTB4 release suppressor from Penic…
5-Lipoxygenase inhibitors: a patent evaluation (WO2011161615).
Structure and function of the oxidation products of polyphenols and identification of potent lipoxyg…
Lipoxygenase inhibitor MK886 potentiates TRAIL-induced apoptosis through CHOP- and p38 MAPK-mediated…
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Clinical Trials
Most Relevant Clinical Trials
Role of 12-lipoxygenase in Platelet Reactivity and Type 2 Diabetes Mellitus
GSK2190915 Safety and Pharmacokinetic Study in Healthy Japanese Subjects
A Single Dose Study to Assess the Regional Absorption and Bioavailability of 100mg GSK2190915A
GSK2190915A - Bioavailability Study
A Repeat Dose Study to Investigate the Interaction of GSK2190915 on the Pharmacokinetics of Rosuvast…
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