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macrocyclic compounds
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Summary
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Genetic Markers
Most Correlated Genes
EGR1
ATF3
CYP26A1
FOS
HSPA1A
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Pathway Enrichment
Most Correlated Biogroups
heterocyclic compound binding
organic cyclic compound binding
organic cyclic compound metabolic process
heterocycle metabolic process
PILON_KLF1_TARGETS_DN
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Curated Studies
Most Correlated Studies
Breast tumors with pathologic complete response (pCR) or residual disease (RD) upon chemotherapy
Attenuation of eIF2 signaling in mice fed high fat diets
AP20187 treatment in wildtype and Atf4 KO mice expressing Fv2E-Perk transgene
Retinoic acid treatment of stellate cells - time course
Docetaxel-resistance in PC-3 and DU-145 prostate cancer cell lines
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Literature
Most Relevant Literature
Riccardin D-26, a synthesized macrocyclic bisbibenzyl compound, inhibits human hepatocellular carcin…
Riccardin D-26, a synthesized macrocyclic bisbibenzyl compound, inhibits human oral squamous carcino…
Macrocyclic glycohybrid toolbox identifies novel antiangiogenesis agents from zebrafish assay.
Macrocyclic mechanism-based inhibitor for neuraminidases.
Recent progress in the discovery of macrocyclic compounds as potential anti-infective therapeutics.
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Clinical Trials
Most Relevant Clinical Trials
IVM Alone vs ALB + IVM Against Onchocerciasis
A Phase 1 Dose Escalation Study of GC4419 in Combination With Chemoradiation for Squamous Cell Cance…
PLX3397 Plus Sirolimus in Unresectable Sarcoma and Malignant Peripheral Nerve Sheath Tumors
Comparison of Prohance® With Gadovist®/Gadavist™ in Magnetic Resonance Imaging (MRI) of the Brain
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