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mitogen-activated protein kinase kinase kinase
Summary
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Curated Studies
Most Correlated Studies
Mitogen-activated protein kinase kinase 4 (MKK4) knockdown in lung cancer cell line 393P
Antitumor efficacy of GDC-0879 involving BRAF mutational status
HEK cells overexpressing kinase dead and WT GRK2 after in vivo expansion and reculturing
Primary macrophages infected with HIV-1 or control for 2,4, or 7d
Acute monocytic leukemia (AML) THP-1 cells HIV gp120 or LPS stimulated following SB203580 treatment
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Literature
Most Relevant Literature
Mixed lineage kinase MLK4 is activated in colorectal cancers where it synergistically cooperates wit…
Serine/Threonine Kinase MLK4 Determines Mesenchymal Identity in Glioma Stem Cells in an NF-κB-depend…
MLK4 as an immune marker and its correlation with immune infiltration in Cervical squamous cell carc…
MLK4 promotes glucose metabolism in lung adenocarcinoma through CREB-mediated activation of phosphoe…
Germline mutations in WNK2 could be associated with serrated polyposis syndrome.
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Clinical Trials
Most Relevant Clinical Trials
p38 Mitogen−Activated Protein Kinase (MAPK) and Steroid Insensitivity in Asthma
Topical Mitogenic-Activated Protein Kinase (MAPK) Inhibition in Rosacea
Phase Ib Study of PI3(Phosphoinositol 3)-Kinase Inhibitor Copanlisib With MEK (Mitogen-activated Pro…
Randomized Phase II Study of AZD6244 (Mitogen-activated Protein Kinase Inhibitor) MEK-Inhibitor With…
Mitogen Activated Protein Kinase Kinase (MEK1/2) Inhibitor Selumetinib (AZD6244 Hydrogen Sulfate) in…
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