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phosphodiesterase type 5 inhibitor
(compound)
Summary
General Info
Genetic Markers
Most Correlated Genes
PDE5A
Sult2a6
FBXW5
SLC22A8
PON1
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Pathway Enrichment
Most Correlated Biogroups
response to organic substance
response to stress
organic cyclic compound metabolic process
LEE_BMP2_TARGETS_DN
response to organic cyclic compound
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Curated Studies
Most Correlated Studies
Quadriceps from DMD[mdx/mdx] mice treated with Tadalafil
Cystic fibrosis bronchial epithelial cells expressing mutant CFTR and treated with small molecules
Livers of rat exposed to variety of hepatotoxic compounds
Drug Matrix In Vivo Toxicogenomic Study - Rat Liver [Affymetrix]
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (1 of 4)
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Literature
Most Relevant Literature
PDE5 inhibitor drugs for use in dementia.
Princeton IV consensus guidelines: PDE5 inhibitors and cardiac health.
Efficacy and safety of PDE5 inhibitors in middle-aged and old patients with and without hypogonadism…
PDE5 inhibitors and male reproduction: Is there a place for PDE5 inhibitors in infertility clinics o…
PDE5 inhibitors: breaking new grounds in the treatment of COVID-19.
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Clinical Trials
Most Relevant Clinical Trials
Study of Add-on Ambrisentan Therapy to Background Phosphodiesterase Type-5 Inhibitor (PDE5i) Therapy…
Efficacy of Phosphodiesterase-type 5 Inhibitors in Patients With Univentricular Congenital Heart Dis…
Use of a Phosphodiesterase Type 5 Inhibitor to Improve Anabolic Resistance in Older Adults
Phosphodiesterase Type-5 Inhibitor Therapy in Sickle Cell People With Pulmonary Hypertension
A Study to Determine if There is a Possible Association Between NAION and Phosphodiesterase Type 5 (…
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