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protein geranylgeranylation
(biogroup)
Summary
General Info
Body Atlas
Most Correlated Tissues
Uterus
Pericardium
Peritoneum
Ileum mucosa
Colon cecum
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Disease Atlas
Most Correlated Diseases
Intestinal infection due to Pseudomonas
Disorder of choroid of eye
Microbial culture finding
Lymphedema
Acute hepatic failure
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Pharmaco Atlas
Most Correlated Compounds
combretastatin A-4
Diterpenes
2-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide
GSK690693
tetrafluoroethylene
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Knockdown Atlas
Most Correlated Gene Perturbations
FAM198B
CHTOP
PPP2R2C
COL7A1
PEX1
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Curated Studies
Most Correlated Studies
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (1 of 4)
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (3 of 4)
L1000 CMAP - Adipocyte ASC cells treated with small molecule perturbagens
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (2 of 4)
L1000 CMAP - Embryonic stem HUES3 cells treated with small molecule perturbagens
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Literature
Most Relevant Literature
Role for protein geranylgeranylation in adult T-cell leukemia cell survival.
Altered Developmental and Metabolic Gene Expression in Basil Interspecific Hybrids.
Protein geranylgeranylation regulates the balance between Th17 cells and Foxp3+ regulatory T cells.
Synthesis of fluorescently tagged isoprenoid bisphosphonates that inhibit protein geranylgeranylatio…
Control of the innate immune response by the mevalonate pathway.
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Clinical Trials
Most Relevant Clinical Trials
Simvastatin + Cetuximab/Irinotecan in K-ras Mutant Colorectal Cancer (CRC)
Phase II Study of Simvastatin Plus Irinotecan, Fluorouracil, and Leucovorin(FOLFIRI) for Metastatic …
Neoadjuvant Zoledronate and Atorvastatin in Triple Negative Breast Cancer
Phase 1 Study of PTX-100 in Patients With Advanced Malignancies
Methotrexate and Statins With Methotrexate Alone in the Treatment of Rheumatoid Arthritis
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