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roscovitine
(compound)
Summary
General Info
Genetic Markers
Most Correlated Genes
NTRK2
AQP1
CRIP1
JCHAIN
CCR7
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Pathway Enrichment
Most Correlated Biogroups
vesicle
extracellular vesicle
MURARO_PANCREAS_DUCTAL_CELL
cell periphery
cytosol
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Curated Studies
Most Correlated Studies
Prostate cancer cell line (LNCaP) treated with trichostatin A or roscovitine, or EZH2 knockdown
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (3 of 4)
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (2 of 4)
L1000 CMAP - Hepatocellular carcinoma HEPG2 cells treated with small molecule perturbagens
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (1 of 4)
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Literature
Most Relevant Literature
Cyclin-dependent kinase inhibitors inspired by roscovitine: purine bioisosteres.
Potent inhibitors of CDK5 derived from roscovitine: synthesis, biological evaluation and molecular m…
Effects of roscovitine, a cell cyclin [correction of cycling]-dependent kinase inhibitor, on intraoc…
Roscovitine in combination with calcium ionophore induces oocyte activation through reduction of M-p…
Raman micro-spectroscopic analysis of cultured HCT116 colon cancer cells in the presence of roscovit…
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Clinical Trials
Most Relevant Clinical Trials
Treatment of Cushing's Disease With R-roscovitine
Evaluation of (R)-Roscovitine Safety and Effects in Subjects With Cystic Fibrosis, Homozygous for th…
Multicenter Study of Seliciclib (R-roscovitine) for Cushing Disease
A Study of Oral Sapacitabine and Oral Seliciclib in Patients With Advanced Solid Tumors
Efficacy Study of Oral Seliciclib to Treat Non-Small Cell Lung Cancer
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