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topoisomerase I
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Curated Studies
Most Correlated Studies
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (3 of 4)
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (2 of 4)
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (1 of 4)
Drug target sets for approved compounds
Gastroesophegeal tumors and adjacent normal tissues before and after chemotreatment
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Literature
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Genome-wide mutagenesis resulting from topoisomerase 1-processing of unrepaired ribonucleotides in D…
High density of unrepaired genomic ribonucleotides leads to Topoisomerase 1-mediated severe growth d…
Apn2 resolves blocked 3' ends and suppresses Top1-induced mutagenesis at genomic rNMP sites.
Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition.
Characterization of DNA topoisomerase I from Mycobacterium tuberculosis: DNA cleavage and religation…
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Clinical Benefit of Topoisomerase Downregulation
Topoisomerase II Alpha Gene Amplification and Protein Overexpression Predicting Efficacy of Epirubic…
Study of Sequential Topoisomerase, Irinotecan/Oxaliplatin - Etoposide /Carboplatin in Extensive Smal…
Phase I Study of Intrathecal Topotecan
Phase I/II Trial of Valproic Acid and Karenitecin for Melanoma
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