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QuickView for topotecan (compound)


Genetic Markers

Most Correlated Genes

  1. GDF15
  2. FOS
  3. LPP
  4. TOP1MT
  5. CDKN1A
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Pathway Enrichment

Most Correlated Biogroups

  1. DACOSTA_UV_RESPONSE_VIA_ERCC3_DN
  2. GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN
  3. DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN
  4. GRYDER_PAX3FOXO1_ENHANCERS_IN_TADS
  5. GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP
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Curated Studies

Most Correlated Studies

  1. Medullary thymic epithelial cells from AIRE knockout mice injected with etoposide and topotecan
  2. Astrocytes from postmortem fetal brains treated with topotecan
  3. Cortical neurons from E13-15 C57BL6J-CASTEiJ hybrid mice undergoing 300nM Topotecan treatment
  4. Bone marrow of rats after topotecan or oxaliplatin single treatment or combination
  5. Cortical neurons treatment with chemicals associated with autism, aging, and neurodegeneration
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Literature

Most Relevant Literature

  1. Topotecan clearance based on a single sample and a population pharmacokinetic model: Application to …
  2. Pharmacokinetics of Orbital Topotecan After Ophthalmic Artery Chemosurgery and Intravenous Infusion …
  3. C60 Fullerene Clusters Stabilize the Biologically Inactive Form of Topotecan.
  4. Enhancement of the Antitumor and Antimetastatic Effect of Topotecan and Normalization of Blood Count…
  5. Synergistic effect of a nonsteroidal anti-inflammatory drug in combination with topotecan on small c…
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Clinical Trials

Most Relevant Clinical Trials

  1. Topotecan With Erlotinib for Topotecan Pretreated Ovarian Cancer
  2. Cabozantinib With Topotecan-Cyclophosphamide
  3. Topotecan Pharmacokinetic Characterization Study
  4. Study of Temsirolimus, Topotecan, and Bortezomib
  5. Open-label Study of Topotecan and Pazopanib in Advanced Solid Tumors
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