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γ secretase
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Curated Studies
Most Correlated Studies
Prostate basal cells treated with a gamma-secretase inhibitor DAPT
T-cell acute lymphoblastic leukemia ALL-SIL cells treated with gamma secretase inhibitor (GSI)
Human embryonic stem cell line H1 treated with gamma-secretase inhibitor DAPT
Pancreatic ductal adenocarcinoma xenografts compared based on resistance or sensitivity to MRK-003
Prefrontal cortex and hippocampus from APLP2 single KO and APPsa knockin in APLP2 KO double mutants
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Literature
Most Relevant Literature
Suspected limited efficacy of γ-secretase modulators.
Design and synthesis of bicyclic heterocycles as potent γ-secretase modulators.
The development of an in vivo γ-secretase assay using zebrafish embryos.
Membrane anchoring γ-secretase modulators with terpene-derived moieties.
Mechanism of intramembrane cleavage of alcadeins by γ-secretase.
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Clinical Trials
Most Relevant Clinical Trials
Phase II Trial of the Gamma-Secretase Inhibitor PF-03084014 in Adults With Desmoid Tumors/Aggressive…
RO4929097 And Exemestane in Treating Pre- and Postmenopausal Patients With Advanced or Metastatic Br…
RO4929097and Bevacizumab in Treating Patients With Progressive or Recurrent Malignant Glioma
Longitudinal Study of Brain Amyloid imaGing in MEMENTO
Phase I Study of Cetuximab With RO4929097 in Metastatic Colorectal Cancer
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