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CDK 4
Summary
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Curated Studies
Most Correlated Studies
A2780 and MCF7 cancer cell lines treated with CDK, HSP90, and topoisomerase inhibitors
HeLa S3 cells depleted of Mediator complex CDKs CDK8 and CDK19
Peripheral blood mononuclear, DU145, and HCT116 cells treated with R547 CDK inhibitor
Clival chordoma UM-Chor1 cells treated with THZ1 or actinomycin D
T cell acute lymphoblastic leukemia MOLT4 cells treated with cyclin-dependent kinase inhibitors
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Literature
Most Relevant Literature
CDK6 inhibits de novo lipogenesis in white adipose tissues but not in the liver.
CDK6: an attractive therapeutic target for T-ALL/LBL.
Development of PROTAC degrader probe of CDK4/6 based on DCAF16.
Broad-spectrum kinome profiling identifies CDK6 upregulation as a driver of lenvatinib resistance in…
CDK6 is a novel predictive and prognosis biomarker correlated with immune infiltrates in multiple hu…
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Clinical Trials
Most Relevant Clinical Trials
Evaluation of Geriatric Questionnaires to Predict Toxicities of CDK 4/6 Inhibitors in Older Breast C…
Study of Ribociclib With Everolimus + Exemestane in HR+ HER2- Locally Advanced/Metastatic Breast Can…
CDK 4/6 Inhibitor, Ribociclib, With Adjuvant Endocrine Therapy for ER-positive Breast Cancer
Utilizing Multiomic Advanced Diagnostics to Identify CDK 4/6 Inhibitor Response Predictors and a Pos…
Safety, Pharmacokinetic and Pharmacodynamic Study of the CDK 4/6 Inhibitor G1T28-1
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