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QuickView for CDK12 (gene)


Body Atlas

Most Correlated Tissues

  1. Basophil of peripheral blood
  2. Natural killer cell of peripheral blood
  3. Dendritic (plasmacytoid) cell
  4. Liver
  5. Leukocyte (polymorphonuclear) of peripheral blood
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Disease Atlas

Most Correlated Diseases

  1. Varicella-zoster virus infection
  2. Cardiac transplant rejection
  3. Body temperature finding
  4. Disease due to Arenavirus
  5. Pulmonary hypertension
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Pharmaco Atlas

Most Correlated Compounds

  1. fipexide
  2. 8-aminohexylamino cAMP
  3. Thiostrepton
  4. Wnt3a protein, mouse
  5. thrombin receptor peptide (42-55)
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Knockdown Atlas

Most Correlated Gene Perturbations

  1. PDSS2
  2. RIPK4
  3. CDK12
  4. PICALM
  5. CDK12
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Curated Studies

Most Correlated Studies

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Literature

Most Relevant Literature

  1. Role and therapeutic potential of CDK12 in human cancers.
  2. BRCA1 or CDK12 loss sensitizes cells to CHK1 inhibitors.
  3. CDK12 regulates alternative last exon mRNA splicing and promotes breast cancer cell invasion.
  4. Engineering an analog-sensitive CDK12 cell line using CRISPR/Cas.
  5. Characterization of human cyclin-dependent kinase 12 (CDK12) and CDK13 complexes in C-terminal domai…
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Clinical Trials

Most Relevant Clinical Trials

  1. Immunotherapy in Patients With Metastatic Cancers and CDK12 Mutations
  2. A Study of CHeckpoint Inhibitors in Men With prOgressive Metastatic Castrate Resistant Prostate Canc…
  3. Abemaciclib With or Without Atezolizumab in Metastatic Castration Resistant Prostate Cancer
  4. Durvalumab and Olaparib for the Treatment of Prostate Cancer in Men Predicted to Have a High Neoanti…
  5. Study of Olaparib in Metastatic Renal Cell Carcinoma Patients With DNA Repair Gene Mutations
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