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QuickView for CHEK2 (gene)


Body Atlas

Most Correlated Tissues

  1. Superior cervical ganglion
  2. Olfactory bulb
  3. Smooth muscle
  4. Appendix
  5. Ciliary ganglion
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Disease Atlas

Most Correlated Diseases

  1. Disease due to Adenovirus
  2. Bacterial infection due to Bacillus
  3. Liver transplant disorder
  4. Primary malignant neoplasm of bone
  5. Hepatocellular dysplasia
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Pharmaco Atlas

Most Correlated Compounds

  1. Taurocholic Acid, Monosodium Salt
  2. Povidone
  3. mevalonolactone
  4. Aminophylline
  5. 5-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one
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Knockdown Atlas

Most Correlated Gene Perturbations

  1. Cyp6g1
  2. AURKB
  3. TPM3
  4. PEX10
  5. PPP1R3C
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Curated Studies

Most Correlated Studies

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Literature

Most Relevant Literature

  1. AR phosphorylation and CHK2 kinase activity regulates IR-stabilized AR-CHK2 interaction and prostate…
  2. High CHK2 protein expression is a strong and independent prognostic feature in ERG negative prostate…
  3. CHK2 is essential for spindle assembly and DNA repair during the first cleavage of mouse embryos.
  4. Deacetylation of CHK2 by SIRT1 protects cells from oxidative stress-dependent DNA damage response.
  5. Antagonistic control of DDK binding to licensed replication origins by Mcm2 and Rad53.
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Clinical Trials

Most Relevant Clinical Trials

  1. Combination of HX008 And Niraparib in GErm-line-mutAted Metastatic Breast Cancer
  2. Study of Olaparib in Metastatic Renal Cell Carcinoma Patients With DNA Repair Gene Mutations
  3. Phase II Trial of Talazoparib in BRCA1/2 Wild-type HER2-negative Breast Cancer and Other Solid Tumor…
  4. Study Estimating Association Between Germline Mutations and PD-L1 Expression in Breast Cancer
  5. Phase II Study of Olaparib and Pembrolizumab in Advanced Melanoma With Homologous Recombination (HR)…
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