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QuickView for Dofetilide (compound)


Genetic Markers

Most Correlated Genes

  1. KCNK2
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Pathway Enrichment

Most Correlated Biogroups

  1. positive regulation of cellular response to hypoxia
  2. Two pore domain potassium channel, TREK
  3. astrocyte projection
  4. REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS
  5. regulation of cellular response to hypoxia
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Curated Studies

Most Correlated Studies

  1. Drug target sets for approved compounds
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Literature

Most Relevant Literature

  1. Strategies to reduce HERG K+ channel blockade. Exploring heteroaromaticity and rigidity in novel pyr…
  2. Dofetilide promotes repolarization abnormalities in perfused Guinea-pig heart.
  3. Ventricular remodelling is a prerequisite for the induction of dofetilide-induced torsade de pointes…
  4. Coronary artery disease potentiates response to dofetilide for rhythm control of atrial fibrillation…
  5. Dofetilide reduces the frequency of ventricular arrhythmias and implantable cardioverter defibrillat…
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Clinical Trials

Most Relevant Clinical Trials

  1. Study of the Electrocardiographic Effects of Ranolazine, Dofetilide, Verapamil, and Quinidine in Hea…
  2. Study of LQT-1213 on Dofetilide-Induced QTc Prolongation in Healthy Adult Subjects and Patients Diag…
  3. Effect of Oral GS-6615 on Dofetilide-Induced QT Prolongation, Safety, and Tolerability in Healthy Ad…
  4. PVI Using Cryoablation Alone in Paroxysmal AF Patients Converted From Persistent AF With Dofetilide
  5. Using an iPhone ECG to Monitor the QT Interval on Dofetilide and Sotalol Patients
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