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GDC 0449
(compound)
Summary
General Info
Genetic Markers
Most Correlated Genes
RMI2
PTGES
LRRC10B
CRYAB
DDIT3
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Pathway Enrichment
Most Correlated Biogroups
DUTERTRE_ESTRADIOL_RESPONSE_24HR_UP
FISCHER_DREAM_TARGETS
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP
KOBAYASHI_EGFR_SIGNALING_24HR_DN
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP
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Curated Studies
Most Correlated Studies
Ptch-deficient medulloblastoma SmoWT-MB cells treated with GDC-0449 or JQ1
Neural 3D tissue constructs from H1 ESC-derived precursor cells treated with neurotoxic chemicals
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Literature
Most Relevant Literature
The Sonic hedgehog pathway inhibitor GDC0449 induces autophagic death in human Medulloblastoma Daoy …
ABTC-0904: targeting glioma stem cells in GBM: a phase 0/II study of hedgehog pathway inhibitor GDC-…
Pharmacokinetics and Biodistribution of GDC-0449 Loaded Micelles in Normal and Liver Fibrotic Mice.
Possible antifibrotic effect of GDC-0449 (Vismodegib), a hedgehog-pathway inhibitor, in mice model o…
Micelle Mixtures for Coadministration of Gemcitabine and GDC-0449 To Treat Pancreatic Cancer.
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Clinical Trials
Most Relevant Clinical Trials
A Study of the Hedgehog Pathway Inhibitor GDC-0449 in Healthy Female Subjects of Non-Childbearing Po…
A Study of Vismodegib (GDC-0449) in Patients With Locally Advanced or Metastatic Basal Cell Carcinom…
A Study of Hedgehog Pathway Inhibitor GDC-0449 in Patients With Locally Advanced or Metastatic Solid…
A Study to Investigate the Effect of GDC-0449 on the QT/QTc Interval in Healthy Female Subjects
A Randomized Phase II Study of Cisplatin and Etoposide in Combination With Either Hedgehog Inhibitor…
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