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QuickView for GDC-0449 (compound)


Genetic Markers

Most Correlated Genes

  1. RMI2
  2. PTGES
  3. LRRC10B
  4. CRYAB
  5. DDIT3
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Pathway Enrichment

Most Correlated Biogroups

  1. DUTERTRE_ESTRADIOL_RESPONSE_24HR_UP
  2. FISCHER_DREAM_TARGETS
  3. GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP
  4. KOBAYASHI_EGFR_SIGNALING_24HR_DN
  5. KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP
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Curated Studies

Most Correlated Studies

  1. Ptch-deficient medulloblastoma SmoWT-MB cells treated with GDC-0449 or JQ1
  2. Neural 3D tissue constructs from H1 ESC-derived precursor cells treated with neurotoxic chemicals
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Literature

Most Relevant Literature

  1. The Sonic hedgehog pathway inhibitor GDC0449 induces autophagic death in human Medulloblastoma Daoy …
  2. ABTC-0904: targeting glioma stem cells in GBM: a phase 0/II study of hedgehog pathway inhibitor GDC-…
  3. Pharmacokinetics and Biodistribution of GDC-0449 Loaded Micelles in Normal and Liver Fibrotic Mice.
  4. Possible antifibrotic effect of GDC-0449 (Vismodegib), a hedgehog-pathway inhibitor, in mice model o…
  5. Micelle Mixtures for Coadministration of Gemcitabine and GDC-0449 To Treat Pancreatic Cancer.
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Clinical Trials

Most Relevant Clinical Trials

  1. A Study of the Hedgehog Pathway Inhibitor GDC-0449 in Healthy Female Subjects of Non-Childbearing Po…
  2. A Study of Vismodegib (GDC-0449) in Patients With Locally Advanced or Metastatic Basal Cell Carcinom…
  3. A Study of Hedgehog Pathway Inhibitor GDC-0449 in Patients With Locally Advanced or Metastatic Solid…
  4. A Study to Investigate the Effect of GDC-0449 on the QT/QTc Interval in Healthy Female Subjects
  5. A Randomized Phase II Study of Cisplatin and Etoposide in Combination With Either Hedgehog Inhibitor…
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