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GDC-0879
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Summary
General Info
Genetic Markers
Most Correlated Genes
MAL
S100A2
RBP4
MUC4
KRT13
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Pathway Enrichment
Most Correlated Biogroups
regulation of nitrogen compound metabolic process
organic cyclic compound binding
heterocyclic compound binding
organic cyclic compound metabolic process
heterocycle metabolic process
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Curated Studies
Most Correlated Studies
Antitumor efficacy of GDC-0879 involving BRAF mutational status
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (3 of 4)
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (2 of 4)
L1000 CMAP - Hepatocellular carcinoma HEPG2 cells treated with small molecule perturbagens
L1000 CMAP - Neural progenitor NPC.CAS9 cells treated with small molecule perturbagens
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Literature
Most Relevant Literature
Validation and application of a liquid chromatography-tandem mass spectrometric method for the deter…
Disposition of GDC-0879, a B-RAF kinase inhibitor in preclinical species.
A novel cell-based assay for the high-throughput screening of epithelial-mesenchymal transition inhi…
Antitumor efficacy of the novel RAF inhibitor GDC-0879 is predicted by BRAFV600E mutational status a…
Targeting a Braf/Mapk pathway rescues podocyte lipid peroxidation in CoQ-deficiency kidney disease.
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Clinical Trials
Most Relevant Clinical Trials
Bioequivalence Study of Clindamycin Phosphate Topical Lotion, 1% in Subjects With Acne Vulgaris
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