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Irinotecan Pathway
Summary
General Info
Curated Studies
Most Correlated Studies
Colon cancer HT 115 cells expressing UGT1A isoform 2 shRNA and treated with SN-38
Drug target sets for approved compounds
Jejunum gene expression in irinotecan-treated rats 6 and 72hr post injection
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Literature
Most Relevant Literature
Gene expression profiling of the irinotecan pathway in colorectal cancer.
Pharmacogenetic profiling across the irinotecan pathway in Asian patients with cancer.
The value of genetic polymorphisms to predict toxicity in metastatic colorectal patients with irinot…
Lessons learned from the irinotecan metabolic pathway.
Irinotecan pathway genotype analysis to predict pharmacokinetics.
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Clinical Trials
Most Relevant Clinical Trials
Bevacizumab and Cetuximab With or Without Irinotecan in Treating Patients With Irinotecan-Refractory…
Study of Carfilzomib With Irinotecan in Irinotecan-Sensitive Malignancies and Small Cell Lung Cancer…
Irinotecan With or Without Panitumumab or Cyclosporine in Treating Patients With Advanced or Metasta…
Irinotecan in Treating Children With Refractory Solid Tumors
RRx-001 in Combination With Irinotecan in Metastatic or Advanced Cancer (PAYLOAD)
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