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MC4R
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Summary
General Info
Body Atlas
Most Correlated Tissues
Extraocular muscle
Superior cervical ganglion
Appendix
Atrioventricular node
Monocyte of peripheral blood
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Disease Atlas
Most Correlated Diseases
Hutchinson-Gilford syndrome
Obesity
Adverse reaction to drug
Infection due to Lactobacillus
Anomaly of chromosome pair 1
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Pharmaco Atlas
Most Correlated Compounds
harringtonine
dibenzothiazyl disulfide
Megestrol Acetate
3,3',4',5-tetrachlorosalicylanilide
1-(5-(2-thenyloxy)-1H-indol-3-yl)propan-2-amine
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Knockdown Atlas
Most Correlated Gene Perturbations
USP27X
CYB561A3
AFF4
BTG1
SUMO2
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Curated Studies
Most Correlated Studies
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Literature
Most Relevant Literature
The Mc4r gene is responsible for the development of experimentally induced testicular teratomas.
Prefrontal cortex melanocortin 4 receptors (MC4R) mediate food intake behavior in male mice.
Hypothalamic POMC neuron-specific knockout of MC4R affects insulin sensitivity by regulating Kir2.1.
Protection against overfeeding-induced weight gain is preserved in obesity but does not require FGF2…
Stimulation of Gs signaling in MC4R cells by DREADD increases energy expenditure, suppresses food in…
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Clinical Trials
Most Relevant Clinical Trials
DAYBREAK: Phase 2 Study in Patients With Specific Gene Defects in the MC4R Pathway
Setmelanotide (RM-493), Melanocortin-4 Receptor (MC4R) Agonist, in Bardet-Biedl Syndrome (BBS) and A…
Phase 3 Crossover Trial of Two Formulations of Setmelanotide in Patients With Specific Gene Defects …
EMANATE: A Study of Setmelanotide in Patients With Specific Gene Variants in the MC4R Pathway
Brain-Derived Neurotrophic Factor in Obesity and Brain Function
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