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QuickView for Mexiletine (compound)


Genetic Markers

Most Correlated Genes

  1. CYP1A1
  2. HIRA
  3. CYP1A2
  4. SCN5A
  5. EGR1
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Pathway Enrichment

Most Correlated Biogroups

  1. cell periphery
  2. organic cyclic compound binding
  3. heterocyclic compound binding
  4. Predicted Gene Targets for miR-181
  5. regulation of nitrogen compound metabolic process
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Curated Studies

Most Correlated Studies

  1. Genomics Assisted Toxicity Evaluation system study - Human Hepatocytes
  2. Drug target sets for approved compounds
  3. Broad Connectivity Map (CMAP 2.0) compound database
  4. Drug Matrix In Vivo Toxicogenomic Study - Rat Heart [Codelink]
  5. Genomics Assisted Toxicity Evaluation system study - Rat Liver Single Dose
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Literature

Most Relevant Literature

  1. Combined modifications of mexiletine pharmacophores for new lead blockers of Na(v)1.4 channels.
  2. Enantioselective drug-protein interaction between mexiletine and plasma protein.
  3. An improved synthesis of m-hydroxymexiletine, a potent mexiletine metabolite.
  4. Inhibition of late sodium current by mexiletine: a novel pharmotherapeutical approach in timothy syn…
  5. Asymmetric hydrolytic kinetic resolution with recyclable macrocyclic Co(III)-salen complexes: a prac…
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Clinical Trials

Most Relevant Clinical Trials

  1. Mexiletine and Non Dystrophic Myotonias
  2. Mexiletine in Sporadic Amyotrophic Lateral Sclerosis (SALS)
  3. Mexiletine in Sporadic Amyotrophic Lateral Sclerosis
  4. Mexiletine for the Treatment of Focal Dystonia
  5. Effectiveness of Mexiletine for Treating People With Non-Dystrophic Myotonia
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