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QuickView for Mexiletine (compound)


Genetic Markers

Most Correlated Genes

  1. CYP1A1
  2. SCN5A
  3. HIRA
  4. EGR1
  5. SEMA5A
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Pathway Enrichment

Most Correlated Biogroups

  1. DACOSTA_UV_RESPONSE_VIA_ERCC3_DN
  2. MODULE_23
  3. MODULE_88
  4. MODULE_55
  5. NUYTTEN_NIPP1_TARGETS_DN
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Curated Studies

Most Correlated Studies

  1. Drug target sets for approved compounds
  2. Genomics Assisted Toxicity Evaluation system study - Human Hepatocytes
  3. Broad Connectivity Map (CMAP 2.0) compound database
  4. Genomics Assisted Toxicity Evaluation system study - Rat Liver Single Dose
  5. Genomics Assisted Toxicity Evaluation system study - Rat Liver Repeat Doses
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Literature

Most Relevant Literature

  1. Enantioselective drug-protein interaction between mexiletine and plasma protein.
  2. An improved synthesis of m-hydroxymexiletine, a potent mexiletine metabolite.
  3. Inhibition of late sodium current by mexiletine: a novel pharmotherapeutical approach in timothy syn…
  4. Asymmetric hydrolytic kinetic resolution with recyclable macrocyclic Co(III)-salen complexes: a prac…
  5. Stereoselective binding of mexiletine and ketoprofen enantiomers with human serum albumin domains.
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Clinical Trials

Most Relevant Clinical Trials

  1. Mexiletine and Non Dystrophic Myotonias
  2. Mexiletine in Sporadic Amyotrophic Lateral Sclerosis (SALS)
  3. Mexiletine in Sporadic Amyotrophic Lateral Sclerosis
  4. Mexiletine for the Treatment of Focal Dystonia
  5. Effectiveness of Mexiletine for Treating People With Non-Dystrophic Myotonia
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