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QuickView for PKC 412 (compound)


Genetic Markers

Most Correlated Genes

  1. CXCL8
  2. ANKRD1
  3. TNF
  4. CTGF
  5. CXCL10
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Pathway Enrichment

Most Correlated Biogroups

  1. DACOSTA_UV_RESPONSE_VIA_ERCC3_DN
  2. BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP
  3. KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_UP
  4. regulation of nitrogen compound metabolic process
  5. DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP
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Curated Studies

Most Correlated Studies

  1. Acute myeloid leukemia MV-4-11 cells with drug sensitivity or resistance to PKC412
  2. Triple negative breast cancer cell lines treated with PKC412
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Literature

Most Relevant Literature

  1. Inhibitory Effect of PKC412 Against Human Acute Leukemia Cell Line HL-60 Cells].
  2. Kinase Inhibition by PKC412 Prevents Epithelial Sheet Damage in Autosomal Dominant Epidermolysis Bul…
  3. ETV6-NTRK3 as a therapeutic target of small molecule inhibitor PKC412.
  4. Sensitivity of AML Cells with FLT3- to PKC412 In Vitro].
  5. The secondary FLT3-ITD F691L mutation induces resistance to AC220 in FLT3-ITD+ AML but retains in vi…
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Clinical Trials

Most Relevant Clinical Trials

  1. Ponatinib for FLT3-ITD Acute Myelogenous Leukemia
  2. Midostaurin in Treating Older Patients With Mutated Acute Myeloid Leukemia Post-Transplant
  3. Cladribine, Idarubicin, Cytarabine, and Venetoclax in Treating Patients With Acute Myeloid Leukemia,…
  4. Gentuzumab Ozogamicin and Midostaurin Combination With Standard Cytarabine and Danunorubi Midostauri…
  5. Midostaurin and Decitabine in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia an…
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