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QuickView for TSC1-TSC2 complex (biogroup)


Body Atlas

Most Correlated Tissues

  1. Dorsal root ganglia
  2. Cerebellum
  3. Fetal brain
  4. Corpus callosum
  5. Trigeminal ganglia
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Disease Atlas

Most Correlated Diseases

  1. Pulmonary lymphangioleiomyomatosis
  2. Neurocutaneous syndrome
  3. Periodontitis
  4. Bovine respiratory syncytial virus disease
  5. Aging
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Pharmaco Atlas

Most Correlated Compounds

  1. meropenem
  2. Didanosine
  3. BMP7 protein, human
  4. 2-aminoacetophenone
  5. Maneb
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Knockdown Atlas

Most Correlated Gene Perturbations

  1. ras
  2. MIR30B
  3. ZCCHC4
  4. YWHAZ
  5. GRN
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Curated Studies

Most Correlated Studies

  1. OMIM - Congenital disorder
  2. Cancer Gene Census - mutations in cancer genes
  3. OMIM - Lung diseases
  4. Mouse Phenotypes - Neurocutaneous syndrome
  5. OMIM - Cortical dysplasia
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Literature

Most Relevant Literature

  1. Deficient TSC1/TSC2-complex suppression of SOX9-osteopontin-AKT signalling cascade constrains tumour…
  2. TRIM31 is upregulated in hepatocellular carcinoma and promotes disease progression by inducing ubiqu…
  3. TBC1D7 Is a Core Subunit of the TSC1-TSC2 Complex.
  4. Identification of regions critical for the integrity of the TSC1-TSC2-TBC1D7 complex.
  5. TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1.
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Clinical Trials

Most Relevant Clinical Trials

  1. Everolimus for Cancer With TSC1 or TSC2 Mutation
  2. Phase 2 Basket Trial of Nab-sirolimus in Patients With Malignant Solid Tumors With Pathogenic Altera…
  3. Everolimus in Patients With Advanced Solid Malignancies With TSC1, TSC2, NF1, NF2, or STK11 Mutation…
  4. Characterization of Patients With Tuberous Sclerosis Complex, Lymphangioleiomyomatosis and Angiomyol…
  5. Biomarkers for Tuberous Sclerosis Complex (BioTuScCom)
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