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QuickView for Tyk2 (gene)


Body Atlas

Most Correlated Tissues

  1. Neutrophil of bone marrow
  2. Dendritic (plasmacytoid) cell
  3. Leukocyte (polymorphonuclear) of peripheral blood
  4. Natural killer cell of peripheral blood
  5. Myeloid cells of peripheral blood
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Disease Atlas

Most Correlated Diseases

  1. Alpha-1-antitrypsin deficiency
  2. Disorder of digestive system
  3. Primary immune deficiency disorder
  4. Fusarium infection
  5. Fungal keratitis
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Pharmaco Atlas

Most Correlated Compounds

  1. Ambroxol
  2. PGF protein, human
  3. dibenz(a,h)anthracene-1,2,3,4-tetrahydro-3,4-diol
  4. Endothelin-2
  5. IL8 protein, human
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Knockdown Atlas

Most Correlated Gene Perturbations

  1. FIGLA
  2. L1TD1
  3. MOV10L1
  4. ZBTB18
  5. MX1
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Curated Studies

Most Correlated Studies

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Literature

Most Relevant Literature

  1. Identification and characterization of TYK2 pseudokinase domain stabilizers that allosterically inhi…
  2. Novel mutations of TYK2 leading to divergent clinical phenotypes.
  3. Novel Small Molecule Tyrosine Kinase 2 Pseudokinase Ligands Block Cytokine-Induced TYK2-Mediated Sig…
  4. Therapeutic Advantage of Tyk2 Inhibition for Treating Autoimmune and Chronic Inflammatory Diseases.
  5. Selective TYK2 inhibitors as potential therapeutic agents: a patent review (2019-2021).
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Clinical Trials

Most Relevant Clinical Trials

  1. Dual JAK1/TYK2 Inhibitor for Cicatricial Alopecia
  2. A Phase 1 Study To Evaluate Tolerability, Safety, And Pharmacokinetics Of Topical PF-06263276 In Hea…
  3. A Study to Investigate the Efficacy and Safety of Brepocitinib in Adults With Dermatomyositis
  4. Clinical Study to Evaluate Blood Concentrations of PF-06700841 After Oral Dose as Different Formulat…
  5. Study of Flonoltinib Maleate Tablets in the Treatment of Severe Novel Coronavirus (COVID-19) Infecti…
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