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azd 6244
(compound)
Summary
General Info
Genetic Markers
Most Correlated Genes
SPRY2
DUSP6
XIST
RBP4
WIF1
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Pathway Enrichment
Most Correlated Biogroups
cytosol
regulation of nitrogen compound metabolic process
cellular aromatic compound metabolic process
heterocycle metabolic process
organic cyclic compound binding
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Curated Studies
Most Correlated Studies
Uveal melanoma cell lines reponses to selumetinib treatment
Oncogenic NRAS signaling in melanoma allograft tumors
Colorectal cancer cells treated with tankyrases and MEK inhibitors
Lungs of mice with TGF-alpha induced fibrosis, treated with MAPK (ARRY) and PI3K (PX-886) inhibitors
Lung cancer HCC827 EGFR-mutant cells following treatment with targeted therapies
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Literature
Most Relevant Literature
Induction of COX-2 by feline calicivirus via activation of the MEK1-ERK1/2 pathway, and attenuation …
The Synergistic Inhibitory Effect of Combining MK-2206 and AZD 6244 in MARIMO Cells Harboring a Calr…
Novel LC-MS/MS method for the determination of selumetinib (AZD6244) in whole blood collected with v…
The MEK1/2 Inhibitor AZD6244 Sensitizes BRAF-Mutant Thyroid Cancer to Vemurafenib.
A phase II trial of selumetinib in children with recurrent optic pathway and hypothalamic low-grade …
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Clinical Trials
Most Relevant Clinical Trials
Temsirolimus/AZD 6244 for Treatment-naive With BRAF Mutant Unresectable Stage IV
Cediranib Maleate and Selumetinib Sulfate in Treating Patients With Solid Malignancies
Selumetinib in Treating Patients With Neurofibromatosis Type 1 and Cutaneous Neurofibroma
Selumetinib Sulfate in Treating Patients With Locally Advanced or Metastatic Pancreatic Cancer With …
Selumetinib Sulfate in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodg…
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