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benzamil
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Summary
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Genetic Markers
Most Correlated Genes
CHAC1
KLHL24
FPR1
LPIN1
SLC7A11
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Pathway Enrichment
Most Correlated Biogroups
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_UP
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_UP
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP
HALLMARK_TNFA_SIGNALING_VIA_NFKB
PODAR_RESPONSE_TO_ADAPHOSTIN_UP
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Curated Studies
Most Correlated Studies
Broad Connectivity Map (CMAP 2.0) compound database
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (3 of 4)
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (2 of 4)
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (1 of 4)
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Literature
Most Relevant Literature
Benzamil-mediated urine alkalization is caused by the inhibition of H+-K+-ATPases.
ENaC expression correlates with the acute furosemide-induced K+ excretion.
Greater natriuretic response to ENaC inhibition in male versus female Sprague-Dawley rats.
Benzamil sensitive ion channels contribute to volume regulation in canine chondrocytes.
Antinociceptive effects of amiloride and benzamil in neuropathic pain model rats.
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There were no clinical trials for benzamil
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