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cyclopamine
(compound)
Summary
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Genetic Markers
Most Correlated Genes
LDLR
CST1
PNLIPRP3
APOA2
FAM111B
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Pathway Enrichment
Most Correlated Biogroups
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP
BERENJENO_TRANSFORMED_BY_RHOA_UP
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP
cytosol
CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_DN
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Curated Studies
Most Correlated Studies
Cyclopamine treatment on a coculture of mesenchymal stem cells (92%) and huvECs (8%)
ESC-derived stage 1 and stage 2 endoderm from SOX17+ precursors
Tooth germ development in the absence of Shh signaling
Zebrafish embryos exposed to hedgehog pathway inhibitors
Neural 3D tissue constructs from H1 ESC-derived precursor cells treated with neurotoxic chemicals
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Literature
Most Relevant Literature
A convenient and efficient one-pot conversion of peimisine into cyclopamine.
Cyclopamine and jervine induce COX-2 overexpression in human erythroleukemia cells but only cyclopam…
Hedgehog targeting by cyclopamine suppresses head and neck squamous cell carcinoma and enhances chem…
Inhibitory effect of cyclopamine on metastatic ability of EC109 cells and its mechanism].
Tandem metathesis reactions of oxabicyclo[2.2.1]heptenes: studies on the spirocyclic core of cyclopa…
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Clinical Trials
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Trial of Patidegib Gel 2%, 4%, and Vehicle to Decrease the Number of Surgically Eligible Basal Cell …
Clinical Trial of Patidegib Gel 2%, 4%, and Vehicle Applied Once or Twice Daily to Decrease the GLI1…
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