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QuickView for gaba b agonist (compound)


Genetic Markers

Most Correlated Genes

  1. CYP2A7
  2. AQP8
  3. SERPINB2
  4. CNOT2
  5. PPP1R3G
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Pathway Enrichment

Most Correlated Biogroups

  1. GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN
  2. organic cyclic compound binding
  3. heterocyclic compound binding
  4. organic cyclic compound metabolic process
  5. heterocycle metabolic process
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Curated Studies

Most Correlated Studies

  1. Liver, spleen, and bone marrow of mice treated with baclofen
  2. Cortical neurons exposed to excitotoxic NMDA and potentially neuroprotective compounds
  3. Drug Matrix In Vivo Toxicogenomic Study - Rat Heart [Codelink]
  4. Broad Connectivity Map (CMAP 2.0) compound database
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Literature

Most Relevant Literature

  1. A deeper insight into how GABA-B receptor agonism via baclofen may affect alcohol seeking and consum…
  2. The GABA-B receptor agonist baclofen helps patients with alcohol use disorder: why these findings ma…
  3. Repositioning of a novel GABA-B receptor agonist, AZD3355 (Lesogaberan), for the treatment of non-al…
  4. Evaluation of the effect of GABA(B) agonists on the vagal nodose C-fibers in the esophagus.
  5. Emerging therapies for GERD.
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Clinical Trials

Most Relevant Clinical Trials

  1. GABA Mechanisms Underlying the Vulnerability to Alcohol Dependence
  2. MENDS Study: Trial in Ventilated ICU Patients Comparing an Alpha2 Agonist Versus a Gamma Aminobutyri…
  3. Treatment of Hepatic Encephalopathy With Flumazenil and Change in Cortical GABA Levels in MRS
  4. Gamma-Amino Butyric Acid (GABA)-A Alpha2/3 Study
  5. A Translational and Neurocomputational Evaluation of a Dopamine Receptor 1 Partial Agonist for Schiz…
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