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gamma secretase
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Curated Studies
Most Correlated Studies
Wildtype and IKAROS-deficient DN3 cells treated with gamma secretase inhibitor
LTED cells treated with gamma-secretase inhibitor or depleted of PBX1
Prostate basal cells treated with a gamma-secretase inhibitor DAPT
Aortic valve interstitial cells treated with gamma-secretase/Notch signaling inhibitor
Dental pulp cells treated with JAG1 and gamma secretase inhibitor DAPT
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Literature
Most Relevant Literature
Suspected limited efficacy of γ-secretase modulators.
Design and synthesis of bicyclic heterocycles as potent γ-secretase modulators.
The development of an in vivo γ-secretase assay using zebrafish embryos.
Membrane anchoring γ-secretase modulators with terpene-derived moieties.
Mechanism of intramembrane cleavage of alcadeins by γ-secretase.
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Clinical Trials
Most Relevant Clinical Trials
Gamma Secretase Inhibitor PF-03084014 in Treating Patients With AIDS-Associated Kaposi Sarcoma
Gamma Secretase Inhibitor RO4929097 in Previously Treated Metastatic Pancreas Cancer
Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients Wit…
BCMA-Specific CAR T-Cells Combined With a Gamma Secretase Inhibitor (JSMD194) to Treat Relapsed or P…
Phase II Trial of the Gamma-Secretase Inhibitor PF-03084014 in Adults With Desmoid Tumors/Aggressive…
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