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incb018424
(compound)
Summary
General Info
Genetic Markers
Most Correlated Genes
XIST
BCL3
CHAC1
ERAP2
KRTAP4-3
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Pathway Enrichment
Most Correlated Biogroups
cell periphery
CHEN_METABOLIC_SYNDROM_NETWORK
NUYTTEN_EZH2_TARGETS_UP
response to organic substance
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN
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Curated Studies
Most Correlated Studies
Pro-B BAF-3 cells overexpressing MPL[W515L] and treated with JAK2 inhibitor INCB18424
Dermal papilla cells from donors in spheres treated with tofacitinib or ruxolitinib
Scalp skin biopsies of alopecia areata patients before and after treatment with ruxolitinib
Skin post-5/6wk or 12wk of treatment with IL-15 pathway inhibitors or PBS following alopecia graft
Skin from alopecia areata allografts treated with ruxolitinib or tofacitinib
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Literature
Most Relevant Literature
Cryptococcal meningoencephalitis associated with the long-term use of ruxolitinib.
Hematologic Malignancies/Pediatric Malignancies. I. Ruxolitinib Therapy for Myelofibrosis and Polyc…
Markers of iron deficiency in patients with polycythemia vera receiving ruxolitinib or best availabl…
Ruxolitinib and Polycation Combination Treatment Overcomes Multiple Mechanisms of Resistance of Panc…
Varicella-zoster virus meningoencephalitis in a patient treated with ruxolitinib.
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Clinical Trials
Most Relevant Clinical Trials
INCB018424 in Patients With Advanced Hematologic Malignancies
A Study Exploring the Safety, Tolerability and Efficacy of a 4 Week Course of INCB018424 in Subjects…
Study to Determine the Safety and Efficacy of INCB018424 in Patients With Polycythemia Vera or Essen…
Study of Ruxolitinib (INCB018424) Administered Orally to Patients With Androgen Independent Metastat…
Study of Ruxolitinib (INCB018424) Sustained Release Formulation in Myelofibrosis Patients
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