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locked nucleic acid
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Summary
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Genetic Markers
Most Correlated Genes
YBX1
RPL7L1
KLF10
YBX1P2
1700001C19Rik
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Pathway Enrichment
Most Correlated Biogroups
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP
PILON_KLF1_TARGETS_DN
nucleoplasm
heterocycle metabolic process
cellular aromatic compound metabolic process
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Curated Studies
Most Correlated Studies
Livers treated with toxic and severely toxic locked nucleic acid (LNA) gapmers
Non-small cell lung cancer in vitro model response to miR-92a inhibition
Breast cancer MDA-MB-231 cells grown in hypoxia with YBX1 shRNA and LNAs targeting tRNA fragments
Livers of mice after treatment with miR-29a miR-29b and miR-29c inhibitor
Breast cancer MDA-MB-231 cells with YBX1 shRNA knockdown and LNAs targeting tRNA fragments
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Literature
Most Relevant Literature
Biological activity and biotechnological aspects of locked nucleic acids.
Antagonism of microRNA function in zebrafish embryos by using locked nucleic acid enzymes (LNAzymes)…
Bias in topoisomerase (TOPO)-cloning of multitemplate PCR products using locked nucleic acid (LNA)-s…
Dynamics and efficiency of hole transport in LNA:DNA hybrid diblock oligomers.
Hole transfer in LNA and 5-Me-2'-deoxyzebularine-modified DNA.
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Clinical Trials
Most Relevant Clinical Trials
Phase 1 Study of EZN-2968 Weekly in Adult Patients With Advanced Solid Tumors or Lymphoma
Long-term Efficacy and Safety of OLE LIB003 in HoFH, HeFH, and High-risk CVD Patients Requiring Furt…
Trial to Evaluate Efficacy and Safety of LIB003, Evolocumab and Alirocumab in High-risk CVD Patients
Study of Efficacy and Safety of LIB003 in Patient With CVD on Statins Requiring Additional LDL-C Red…
Study of Long-Term Efficacy and Safety of LIB003 in CVD or High Risk for CVD Patients Needing Furthe…
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