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1. Development of a Series of Pyrrolopyridone MAT2A Inhibitors.
2. Discovery of novel MAT2A inhibitors by an allosteric site-compatible fragment growing approach.
3. Discovery of novel methionine adenosyltransferase 2A (MAT2A) allosteric inhibitors by structure-base…
4. Identification of a Sonically Activated Degrader of Methionine Adenosyltransferase 2A by an in Silic…
5. Blocking methionine catabolism induces senescence and confers vulnerability to GSK3 inhibition in li…

1. AMG 193, Methylthioadenosine (MTA) Cooperative Protein Arginine Methyltransferase 5 (PRMT5) Inhibito…
2. An Investigational Study of BGB-58067 in Participants With Advanced Solid Tumors