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mln8054
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Genetic Markers
Most Correlated Genes
MAL
SPRR3
CRIP1
S100A2
RBP4
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Pathway Enrichment
Most Correlated Biogroups
regulation of nitrogen compound metabolic process
cytosol
organic cyclic compound binding
heterocyclic compound binding
cell periphery
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Curated Studies
Most Correlated Studies
L1000 CMAP - Umbilical vein endothelial HUVEC cells treated with small molecule perturbagens
L1000 CMAP - Bone marrow CD34 cells treated with small molecule perturbagens
L1000 CMAP - Adipocyte ASC cells treated with small molecule perturbagens
L1000 CMAP - Neural progenitor NPC cells treated with small molecule perturbagens
L1000 CMAP - Neuronal NEU cells treated with small molecule perturbagens
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Literature
Most Relevant Literature
Aurora A inhibition disrupts chromosome condensation and spindle assembly during the first embryonic…
Phosphorylation, Mg-ADP, and Inhibitors Differentially Shape the Conformational Dynamics of the A-Lo…
Molecular dynamics and free energy studies on Aurora kinase A and its mutant bound with MLN8054: ins…
Phase I assessment of new mechanism-based pharmacodynamic biomarkers for MLN8054, a small-molecule i…
Phosphorylation of Merlin by Aurora A kinase appears necessary for mitotic progression.
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Clinical Trials
Most Relevant Clinical Trials
A Study of MLN8054 in Patients With Advanced Solid Tumors
A Phase 1 Trial of Extended MLN8054 Dosing in Patients With Advanced Malignancies
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