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QuickView for pde3 inhibitor (compound)


Genetic Markers

Most Correlated Genes

  1. PDE4B
  2. PPP2CA
  3. DDX27
  4. ROCK2
  5. UBR2
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Pathway Enrichment

Most Correlated Biogroups

  1. regulation of nitrogen compound metabolic process
  2. response to organic substance
  3. organic cyclic compound binding
  4. organic cyclic compound metabolic process
  5. regulation of RNA biosynthetic process
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Curated Studies

Most Correlated Studies

  1. Hearts of rats exposed variety of toxicants
  2. L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (1 of 4)
  3. L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (2 of 4)
  4. L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (3 of 4)
  5. Drug Matrix In Vivo Toxicogenomic Study - Rat Heart [Affymetrix]
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Literature

Most Relevant Literature

  1. Treatment of Cardiovascular Dysfunction with PDE3-Inhibitors in Moderate and Severe Hypothermia-Effe…
  2. PDE3-inhibitor enoximone prevented mechanical ventilation in patients with SARS-CoV-2 pneumonia.
  3. PDE3 Inhibitors Repurposed as Treatments for Age-Related Cognitive Impairment.
  4. K-134, a phosphodiesterase 3 inhibitor, prevents brain damage by inhibiting thrombus formation in a …
  5. Phosphodiesterase-3 inhibitor].
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Clinical Trials

Most Relevant Clinical Trials

  1. Influence of a Prematuration Culture With a Phosphodiesterase-3 Inhibitor (PDE3-I) on Embryonic Aneu…
  2. Influence of a Prematuration Culture With a Phosphodiesterase-3 Inhibitor (PDE3-I) on Embryonic Aneu…
  3. The Phosphodiesterase-3 Inhibitor Cilostazol as an Adjunctive to Antidepressants in Patients With Ma…
  4. The DPP-4 Inhibitor Vildagliptin as Adjunct in Major Depressive Disorder Patients
  5. Dose Ranging Study of RPL554 in Chronic Obstructive Pulmonary Disease (COPD) Patients
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