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QuickView for polymyxin (compound)


Genetic Markers

Most Correlated Genes

  1. MBL1P
  2. UBR2
  3. GHR
  4. EGR1
  5. KCNH6
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Pathway Enrichment

Most Correlated Biogroups

  1. DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP
  2. response to extracellular stimulus
  3. SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN
  4. GSE13547_CTRL_VS_ANTI_IGM_STIM_BCELL_12H_UP
  5. response to organic substance
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Curated Studies

Most Correlated Studies

  1. Liver Pharmacology and Xenobiotic Response Repertoire
  2. Kidneys from C57BL6 mice treated intraperitoneally with colistin sulfate
  3. Drug Matrix In Vivo Toxicogenomic Study - Rat Liver [Codelink]
  4. Broad Connectivity Map (CMAP 2.0) compound database
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Literature

Most Relevant Literature

  1. Abh, AbrB3, and Spo0A play distinct regulatory roles during polymyxin synthesis in Paenibacillus pol…
  2. Recent Advances in the Development of Polymyxin Antibiotics: 2010-2023.
  3. Advances in the clinical treatment of multidrug-resistant pathogens using polymyxins.
  4. Arginine catabolism is essential to polymyxin dependence in Acinetobacter baumannii.
  5. A multi-valent polymyxin-based fluorescent probe for the detection of Gram-negative infections.
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Clinical Trials

Most Relevant Clinical Trials

  1. Optimizing Clinical Use of Polymyxin B
  2. Melatonin for Renal Protection in Patients Receiving Polymyxin B
  3. A Pharmacokinetic Study of Polymyxin B in Healthy Subjects and Subjects With Renal Insufficiency
  4. Inhaled Polymyxin E to Prevent VAP
  5. Polymyxin B Monotherapy vs Combination Therapy in Critically Ill Patients With Multi-drug Resistant …
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