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pregnenolone
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Summary
General Info
Genetic Markers
Most Correlated Genes
CYP2B6
DBP
GADD45B
CYP2C18
Ces2a
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Pathway Enrichment
Most Correlated Biogroups
WENG_POR_TARGETS_LIVER_UP
WENG_POR_TARGETS_GLOBAL_UP
MODULE_24
UEDA_PERIFERAL_CLOCK
steroid metabolic process
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Curated Studies
Most Correlated Studies
Livers from PXR KO mice undergoing pregnenolone 16alpha-carbinonitrile (PCN) treatment
Liver from mice treated with PXR or CAR ligands
Livers exposed to CAR agonist TCPOBOP or PXR agonist pregnenolone 16alpha-carbonitrile
Liver tissues from rats after treatment with different compounds
Hepatocytes isolated from rats and treated with 29 ToxCast chemicals in a dose-dependent manner
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Literature
Most Relevant Literature
Genetic defects in pregnenolone synthesis.
Inhibition by pregnenolone sulphate, a metabolite of the neurosteroid pregnenolone, of voltage-gated…
3β-Methoxy-pregnenolone (MAP4343) as an innovative therapeutic approach for depressive disorders.
Pregnenolone rescues schizophrenia-like behavior in dopamine transporter knockout mice.
Glibenclamide-pregnenolone derivative has greater hypoglycemic effects and biodistribution than glib…
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Clinical Trials
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Development of Pregnenolone as a Treatment for Depression R61
A Study of Pregnenolone in the Treatment of Individuals With Autism
Pregnenolone for the Treatment of Alcohol Use Disorder
Study Using Pregnenolone to Treat Bipolar Depression
Pilot Trial of Pregnenolone in Autism
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