QuickView for proto oncogene proteins b- raf

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1. Structure-based de novo design and biochemical evaluation of novel BRAF kinase inhibitors.
2. Vemurafenib (RG67204, PLX4032): a potent, selective BRAF kinase inhibitor.
3. Design, synthesis and biological evaluation of β-carboline derivatives as novel inhibitors targeting…
4. Identification of novel BRAF kinase inhibitors with structure-based virtual screening.
5. An activated mutant BRAF kinase domain is sufficient to induce pilocytic astrocytoma in mice.

1. Trametinib for Pediatric Neuro-oncology Patients With Refractory Tumor and Activation of the MAPK/ER…
2. Randomized Phase II Study of AZD6244 (Mitogen-activated Protein Kinase Inhibitor) MEK-Inhibitor With…
3. Ibrutinib in Treating Patients With Refractory Metastatic Cutaneous Melanoma
4. Rituximab and Hyaluronidase Human in Patients With Advanced Melanoma Undergoing Nivolumab and Ipilim…
5. Evaluation of a Promising New Combination of Protein Kinase Inhibitors on Organotypic Cultures of Hu…