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replication fork arrest
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Summary
General Info
Body Atlas
Most Correlated Tissues
Endometrium
Peritoneum
Kidney
Hematopoietic stem cell of bone marrow
Ascending colon
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Disease Atlas
Most Correlated Diseases
Rhinitis
Bacterial infection due to Bacillus
Inflammatory disorder
Vesicular stomatitis Indiana virus disease
Myocardial ischemia
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Pharmaco Atlas
Most Correlated Compounds
N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N1-(2-fluoro-5-methylphenyl)urea
Butylhydroxybutylnitrosamine
25-hydroxycholesterol
phorbolol-12-myristate-13-acetate
Antigens, Viral, Tumor
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Knockdown Atlas
Most Correlated Gene Perturbations
AURKB
PIR
POU4F3
IGH
MIR30A
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Curated Studies
Most Correlated Studies
Acute myeloid leukemia MV4-11 cells treated with BSJ-03-123, YKL-06-102 and palbociclib
Prostate cancer stem cells from TRAMP mice with intraepithelial neoplasia or neuroendocrine tumors
CD4+ T cells from Sle1b (lupus prone), Sle1b.BACSlamf6-H1 (rescued) and normal B6 mice
Lung fibroblast IMR90 cells depleted of TP53 in senescent, quiescent or apoptosis-sensitive states
Melanoma A375 cells with p53, CDT1 or BRCA1 knockdown and daunorubicin, nutlin or MLN4924 treatment
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Literature
Most Relevant Literature
Nucleoid occlusion prevents cell division during replication fork arrest in Bacillus subtilis.
The Escherichia coli GTPase ObgE modulates hydroxyl radical levels in response to DNA replication fo…
Enhanced H2AX phosphorylation, DNA replication fork arrest, and cell death in the absence of Chk1.
DNA replication fork arrest by the Bacillus subtilis RTP-DNA complex involves a mechanism that is in…
Accumulation of FFA-1, the Xenopus homolog of Werner helicase, and DNA polymerase delta on chromatin…
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Clinical Trials
Most Relevant Clinical Trials
Study of AZD6738, DNA Damage Repair/Novel Anti-cancer Agent, in Combination With Paclitaxel, in Refr…
Lurbinectedin With Berzosertib, an ATR Kinase Inhibitor in Small Cell Cancers and High-Grade Neuroen…
A Phase 1/2 Trial of SRA737 in Combination With Gemcitabine Plus Cisplatin or Gemcitabine Alone in S…
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