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QuickView for second generation antihistamines (compound)


Genetic Markers

Most Correlated Genes

  1. HRH1
  2. DBP
  3. ATF3
  4. FOS
  5. IFIT1
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Pathway Enrichment

Most Correlated Biogroups

  1. DODD_NASOPHARYNGEAL_CARCINOMA_DN
  2. regulation of nitrogen compound metabolic process
  3. heterocycle metabolic process
  4. heterocyclic compound binding
  5. response to organic substance
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Curated Studies

Most Correlated Studies

  1. Cerebrocortical cells treated with blood-brain barrier penetrant clinic-tested drugs
  2. Hearts of rats exposed variety of toxicants
  3. Drug Matrix In Vitro Toxicogenomic Study - Rat Hepatocytes [Codelink]
  4. Drug target sets for approved compounds
  5. Broad Connectivity Map (CMAP 2.0) compound database
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Literature

Most Relevant Literature

  1. Seizures induced by desloratadine, a second-generation antihistamine: clinical observations.
  2. Urticaria and its subtypes: the role of second-generation antihistamines.
  3. Pharmacological rationale for the treatment of chronic urticaria with second-generation non-sedating…
  4. Efficacy of second-generation antihistamines in patients with allergic rhinitis and comorbid asthma.
  5. Second-generation antihistamines for the treatment of chronic idiopathic urticaria.
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Clinical Trials

Most Relevant Clinical Trials

  1. Effects of Second-generation Antihistamine Bepotastine on Cough Outcomes in Cough Patients With Alle…
  2. A Safety and Efficacy Study of Remibrutinib in the Treatment of CSU in Japanese Adults Inadequately …
  3. This Was a Dose-finding Study to Evaluate Efficacy and Safety of LOU064 in Patients With CSU Inadequ…
  4. A Phase 3 Study of Efficacy and Safety of Remibrutinib in the Treatment of CSU in Adults Inadequatel…
  5. A Phase 3 Study of Efficacy and Safety of Remibrutinib in the Treatment of CSU in Adults Inadequatel…
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