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sodium channel blockers
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NextBio Summary
General Info
Genetic Markers
Most Correlated Genes
PPP2CA
SCN5A
TMEM8A
ADCY10
DLX5
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Pathway Enrichment
Most Correlated Biogroups
regulation of nitrogen compound metabolic process
organic cyclic compound metabolic process
heterocycle metabolic process
heterocyclic compound binding
organic cyclic compound binding
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Curated Studies
Most Correlated Studies
Cerebellar after ventral hippocampal lesion or tetrodotoxin disruption, or neuroleptics trea
Hippocampal neurons in culture with TET3 shRNA and/or bicuculline or tetrodotoxin treated
Drug target sets for approved compounds
Drug Matrix In Vivo Toxicogenomic Study - Rat Heart [Codelink]
Multiple myeloma KMS12-BM and plasma cell leukemia JJN3 cells treated with amiloride and TG003
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Literature
Most Relevant Literature
Efficacy of sodium channel blockers in SCN2A early infantile epileptic encephalopathy.
Dibenzazepines and dibenzoxazepines as sodium channel blockers.
Sodium channel blockers: a patent review (2010 - 2014).
Sodium channel blockers for neuroprotection in multiple sclerosis.
N-Aryl azacycles as novel sodium channel blockers.
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Clinical Trials
Most Relevant Clinical Trials
Efficacy Study of Sodium Channel Blocker in LQT3 Patients
Classical Trigeminal Neuralgia and Sodium Channel Mutations
Expanded Access Use of Stiripentol in Dravet Syndrome or Sodium Channel Mutation Epileptic Encephalo…
Calcium Channel Blockade in Primary Aldosteronism
Benidipine-based Comparison of Angiotensin Receptors, β-blockers, or Thiazide Diuretics in Hypertens…
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